Genetic risk factors for Mesoamerican nephropathy
Friedman DJPapers in this archive, Leone DAPapers in this archive, Amador JJPapers in this archive, Kupferman JPapers in this archive, Francey LJPapers in this archive, Lopez-Pilarte DPapers in this archive, Lau JPapers in this archive, Delgado IPapers in this archive, Yih WKPapers in this archive, Salinas APapers in this archive, Wang MPapers in this archive, Genovese GPapers in this archive, Shah SPapers in this archive, Kelly JPapers in this archive, Tattersfield CFPapers in this archive, Raines NHPapers in this archive, Amador MPapers in this archive, Dias LPapers in this archive, Pitsillides APapers in this archive, Ramirez-Rubio OPapers in this archive, Amador AGPapers in this archive, Cortopassi MPapers in this archive, Applebaum KMPapers in this archive, Alper SLPapers in this archive, Banks ASPapers in this archive, McClean MDPapers in this archive, Leibler JHPapers in this archive, Scammell MKPapers in this archive, Dupuis JPapers in this archive, Brooks DRPapers in this archive
Abstract
There is an extreme clustering of kidney disease in otherwise healthy young manual laborers in Central America known as Mesoamerican nephropathy (MeN). Environmental factors are the main suspect, particularly exposure to heavy labor in high heat. We found that this disease also has a strong genetic component. Native American ancestry is a strong risk factor for MeN. Genetic variants in a gene called OPCML may help protect against MeN, potentially by preventing dehydration and increasing tolerance to heat. Our data suggest that genetic factors are important for tolerance of heat stress and that populations have differential susceptibility to kidney injury based on these genetic factors. Keywords: kidney disease, genetics, Mesoamerican, OPCML
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