Preserving Fossilized Soft Tissues: Advancing Proteomics and Unveiling the Evolutionary History of Cancer in Dinosaurs
Chandrasinghe PC, Cereser B, Bertazzo S, Csiki-Sava Z, Stebbing J.
Abstract
This study explores how cancer in dinosaurs can offer insights into the evolutionary history of disease and life-history strategies. By using paleoproteomics to analyze preserved proteins in fossils, researchers are uncovering the molecular markers of disease in ancient species. The discovery of tumors, particularly in hadrosaurs and the recent finding in Telmatosaurus transsylvanicus, highlights the potential of studying cancer in extinct species. The integration of life-history theory with advanced proteomic methods aims to reveal how evolutionary trade-offs influenced cancer susceptibility and may uncover new mechanisms of cancer suppression. The research emphasizes the importance of preserving fossilized tissues and advancing proteomic techniques to understand the evolution of cancer and improve modern disease prevention. Keywords: paleopathology, paleoproteomics, fossils, evolutionary biology of cancers
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