2026·American journal of human genetics
Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles
Font-Porterias N, Nemat-Gorgani N, Kichula KM, Al-Hindi DR, Harrison GF, Tao S, Zhu F, Montero-Martin G, Fernández-Viña MA, Guethlein LA, Parham P, Oppenheimer SJ, Ioannidis AG, Moreno-Estrada A, Pomat W, Mentzer AJ, Henn BM, Norman PJ.
Read at the journaldoi:10.1016/j.ajhg.2026.04.006
Abstract
Polymorphism of human leukocyte antigens (HLA) guides differential immune responses to infection. We analyze how HLA evolved across the distinct environments of Papua New Guinea. We find that HLA diversity correlates with altitude and that naturally selected variants may confer protection against malaria in the lowland region.
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