Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles
Font-Porterias NPapers in this archive, Nemat-Gorgani NPapers in this archive, Kichula KMPapers in this archive, Al-Hindi DRPapers in this archive, Harrison GFPapers in this archive, Tao SPapers in this archive, Zhu FPapers in this archive, Montero-Martin GPapers in this archive, Fernández-Viña MAPapers in this archive, Guethlein LAPapers in this archive, Parham PPapers in this archive, Oppenheimer SJPapers in this archive, Ioannidis AGPapers in this archive, Moreno-Estrada APapers in this archive, Pomat WPapers in this archive, Mentzer AJPapers in this archive, Henn BMPapers in this archive, Norman PJPapers in this archive
Abstract
Polymorphism of human leukocyte antigens (HLA) guides differential immune responses to infection. We analyze how HLA evolved across the distinct environments of Papua New Guinea. We find that HLA diversity correlates with altitude and that naturally selected variants may confer protection against malaria in the lowland region.
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