The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior
Ju XCPapers in this archive, Lee SYPapers in this archive, Ågren RPapers in this archive, Machado LCPapers in this archive, Xing JPapers in this archive, Azama CPapers in this archive, Roy MCPapers in this archive, Endo TPapers in this archive, Huttner WPapers in this archive, Siepel APapers in this archive, Fukunaga IPapers in this archive, Zeberg HPapers in this archive, Pääbo SPapers in this archive
Abstract
An amino acid substitution and noncoding changes have reduced adenylosuccinate lyase activity in modern humans after the divergence from Neandertals and Denisovans. This resulted in increased concentrations of purine substrates of the enzyme, particularly in the brain. When introduced into mice, the amino acid substitution causes females to access water more readily than their wild-type littermates.
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